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Guangdong Acad Med Sci, Guangdong Prov Key Lab South China Struct Heart D, Dept Cardiovasc Dis Epidemiol, Guangdong Cardiovasc Inst,Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China Guangdong Acad Med Sci, Guangdong Prov Key Lab South China Struct Heart D, Dept Cardiovasc Dis Epidemiol, Guangdong Cardiovasc Inst,Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China