Synthesis of some novel fluorinated pyrazolo[3,4-b]pyridines

被引：26

作者：

Singh, SP

Naithani, R ^{[1
]}

Aggarwal, R

Prakash, O

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

[2] Kurukshetra Univ, Dept Chem, Kurukshetra 132119, Haryana, India

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 23期

关键词：

alpha-cyanoacetophones; fluorinated-beta-diketones; pyrazolo[3,4-b]pyrimidines;

D O I：

10.1081/SCC-200039427

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 5-amino-3-substituted pyrazoles (1a-c) and 5-amino-1,3-disubstituted pyrazoles (1d-i) with fluorinated-beta-diketones (2) results in the formation of the single isomer of pyrazolo[3,4-b]pyridines (4a-h). A one-pot procedure for the synthesis of title compounds starting from alpha-cyanoacetophenones along with a possible mechanistic pathway for the formation of the title compounds is described.

引用

页码：4359 / 4367

页数：9

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