Free-radical and biochemical reactions involving polar part of glycerophospholipids

The review summarizes and critically discusses data on biochemical and free-radical transformations of glycerophospholipids. The results presented therein demonstrate that hydroxyl-containing glycerophospholipids, such as cardiolipin, lyso-lipids and others, can undergo fragmentation upon interaction with radical agents forming the biologically active products. Hydrolysis of glycerophospholipids catalyzed by different phospholi-pases was shown to yield compounds, which can be involved in the free-radical fragmentation leading to significant changes in structures of original lipids.