Toxicity of purified terephthalic acid manufacturing wastewater on reproductive system of male mice (Mus musculus)

被引：36

作者：

Zhang, Xu-Xiang ^{[1
]}

Sun, Shi-Lei ^{[2
]}

Zhang, Yan ^{[1
]}

Wu, Bing ^{[1
]}

Zhang, Zong-Yao ^{[1
]}

Liu, Bo ^{[1
]}

Yang, Liu-Yan ^{[1
]}

Cheng, Shu-Pei ^{[1
]}

机构：

[1] Nanjing Univ, Inst Environm Hlth & Ecol Secur, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210093, Jiangsu, Peoples R China

[2] Jiangsu Suyuan Environemental Protect Engn Co Ltd, Water Res & Dev Ctr, Nanjing 210093, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2010年 / 176卷 / 1-3期

关键词：

Purified terephthalic acid; Reproductive toxicity; Spermatogenic cells; Wastewater; SPERMATOGENIC CELLS; RISK-ASSESSMENT; MOUSE; RATS; EXPOSURE; CYTOTOXICITY; PRETREATMENT; WASTEWATERS; EFFLUENTS; WORKERS;

D O I：

10.1016/j.jhazmat.2009.11.028

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Reproductive toxicity of purified terephthalic acid (PTA) manufacturing wastewater on the male mice (Mus musculus) was investigated after 35-day intragastric perfusion treatment with the wastewater. Fluorescein diacetate and propidium iodide staining, and flow cytometry were used to assess the toxicity of PTA wastewater on spermatogenic cells. PTA wastewater induced significant variations in the relative percentages of immature haploid, diploid, tetraploid and S-phase spermatogonia. Percentage of viable spermatogenic cells was reduced from 93.1 +/- 2.3 in control group to 90.4 +/- 1.9 in the wastewater-treated group. Testicular histopathology revealed expansion of interstitial space and reduction in the number and size of Leydig cells induced by the wastewater. which was further certified by the decrease (10.6%) in relative testes weight and the increase (101.3%) in sperm shape abnormality in the wastewater-treated group. In this study, PTA wastewater was found to have reproductive toxicity on male mice, and public health problems may potentially arise from the discharge of the wastewater into the environment. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：300 / 305

页数：6

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