Sickle cell disease: Continuous arterial spin-labeling perfusion MR imaging in children

被引：83
|
作者：
Oguz, KK
Golay, X
Pizzini, FB
Freer, CA
Winrow, N
Ichord, R
Casella, JF
van Zijl, PCM
Melhem, ER
机构：
[1] Johns Hopkins Med Inst, Dept Radiol & Radiol Sci, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Pediat, Div Pediat Hematol, Baltimore, MD 21205 USA
[3] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA
[4] Childrens Hosp Philadelphia, Dept Pediat & Neurol, Philadelphia, PA USA
[5] Univ Penn, Philadelphia, PA 19104 USA
来源：
RADIOLOGY | 2003年 / 227卷 / 02期
关键词：
magnetic resonance (MR); in infants and children; perfusion study; cerebral blood vessels; flow dynamics; MR; sickle cell disease (SS; SC);
D O I：
10.1148/radiol.2272020903
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Cerebral blood flow (CBF) was measured with continuous arterial spin-labeling perfusion magnetic resonance (MR) imaging in 14 children with sickle cell disease and seven control subjects. Mean CBF values were higher in patients (P <.005) than in control subjects in all cerebral artery territories. Three patients had decreased CBF in right anterior and middle cerebral artery territories compared with CBF on the left, and one patient had a profound decrease in CBF in all three territories in the right hemisphere. Base; line CBF was significantly decreased in territories seen as unaffected on conventional MR images and MR angiograms in four children with sickle cell disease.
引用
收藏
页码：567 / 574
页数：8
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