DNA microarray gene expression analysis of human vascular endothelial cells exposed to arsenite

被引：4
|
作者：
Fujiwara, Yasuyuki [1 ]
Honda, Akiko [1 ]
Satoh, Masahiko [1 ]
机构：
[1] Aichi Gakuin Univ, Sch Pharm, Lab Pharmaceut Hlth Sci, Chikusa Ku, Aichi 4648650, Japan
来源：
JOURNAL OF TOXICOLOGICAL SCIENCES | 2010年 / 35卷 / 02期
关键词：
Arsenite; DNA microarray; Human vascular endothelial cell; Atherosclerosis;
D O I：
10.2131/jts.35.275
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
DNA microarray was used to monitor the transcriptional response of human brain microvascular endothelial cells (HBMEC) and human coronary artery endothelial cells (HCAEC) to sodium arsenite (iAs(III)). iAs(III) enhanced the expression of 10 and 6 genes, and reduced the expression of 45 and 20 genes in HBMEC and HCAEC, respectively. Among the 64 genes whose expression was changed in some way, HBMEC and HCAEC had 5 up-regulated and 12 down-regulated genes in common.
引用
收藏
页码：275 / 278
页数：4
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