Lichen sclerosus -: Present-day hormonal therapy

Several treatment modalities of lichen sclerosus have been described, Topical testosterone (2%) has been the therapy of choice with improvement of symptoms in 67-100% of the patients. Newer placebo-controlled studies report success rates for testosterone of 20% which is not much higher than for placebo (10%). Treatment with the very potent steroidlike clobetasol 0.05% has been shown to be much more effective with success rates of up to 75%, while corticosteroid-related side effects like skin atrophy have not been a major problem. Copyright (C) 2000 S. Karger AG, Basel.