An immunogenicity study of a newly introduced purified vero cell rabies vaccine (Abhayrab) manufactured in India

被引：18
|
作者：
Sampath, G [1 ]
Reddy, SV
Rao, MLP
Rao, YU
Palaniappan, C
机构：
[1] Inst Prevent Med, Hyderabad, Andhra Pradesh, India
[2] Inst Pasteur India, Tamil Nadu, India
来源：
VACCINE | 2005年 / 23卷 / 07期
关键词：
post-exposure rabies treatment; rabies tissue culture vaccine; rabies in India;
D O I：
10.1016/j.vaccine.2004.08.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Purified Vero cell culture rabies vaccine "Abhayrab" manufactured by Human Biologicals Institute, Ooty, India was subjected for immunogenicity studies. Pre-exposure study was undertaken on 60 healthy volunteers (Group I) with vaccination on days 0, 7 and 21. A group of 75 patients of category II (Group II), 67 of category III (Group III) were given post-exposure prophylaxis and 88 patients of category III were administered with rabies immunoglobulins (Group IV) along with post-exposure prophylaxis as per World Health Organization (WHO) recommendations with a booster on day 90. The volunteers and patients vaccinated showed very few adverse side effects. The blood samples collected from volunteers (Group I) on days 14, 35 and 365 and patients (Group II-IV) on days 14, 30, 90 and 365 showed geometric mean titres (GMT) of >0.5 IU/ml. The study indicated new rabies vaccine manufactured in India was found to be safe and immunogenic. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：897 / 900
页数：4
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