Synthesis and Chemical Reactivity of New Azaenamines Incorporated the 4,5,6,7-Tetrahydrobenzo[b]thiophene Moiety: 3+3 Atom Combination

被引：45
|
作者：
Abdelhamid, Ismail Abdelshafy [1 ,2 ]
Darwish, Elham Sayed [1 ]
Nasra, Miead Adel [1 ]
Abdel-Gallil, Fathy Mohamed [1 ]
Fleita, Daisy Hanna [3 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
[2] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
[3] Amer Univ Cairo, Dept Chem, Cairo, Egypt
来源：
SYNTHESIS-STUTTGART | 2010年 / 07期
关键词：
azaenamine; tetrahydrobenzo[b]thiophene; Michael addition; condensation; Mannich alkylation; MANNICH-TYPE REACTION; DERIVATIVES; PYRIDAZINES; CHITOSAN; CATALYST; AMINES; ACID;
D O I：
10.1055/s-0029-1219235
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel azaenamines incorporating a tetrahydrothiophene moiety were prepared. Michael addition of an azaenamine with alpha,beta-unsaturated nitriles took place to give [1]benzothieno[3',2':5,6]pyrimido[1,2-b]pyridazine (thia- triaza-benzo[a]fluorene) derivatives. The condensation with malononitrile resulted in the formation of a [1]benzothieno[3',2':5,6]pyrimido[1,2-b]pyridazine-4-carbonitrile. The azaenamine also reacted with aldehydes and piperidine to give Mannich products.
引用
收藏
页码：1107 / 1112
页数：6
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