An evidence-based framework to evaluate Melanocortin-4 Receptor (MC4R) pathway relevance for obesity-associated genes

被引:1
|
作者
Vogel, Megan [1 ]
Moeller, Ida [1 ]
Garfield, Alastair [1 ]
Shah, Bhavik [1 ]
机构
[1] Rhythm Pharmaceut, Boston, MA USA
关键词
D O I
10.1016/j.gim.2022.01.447
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
eP412
引用
收藏
页码:S259 / S259
页数:1
相关论文
共 50 条
  • [21] Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (PPAR-γ), the fat mass and obesity-associated (FTO), and the melanocortin-4 receptor (MC4R) genes
    Szkup, Malgorzata
    Owczarek, Aleksander Jerzy
    Schneider-Matyka, Daria
    Brodowski, Jacek
    Loj, Beata
    Grochans, Elzbieta
    AGING-US, 2018, 10 (01): : 72 - 82
  • [22] Analysis of variation in the melanocortin-4 receptor gene (mc4r) in golden retriever dogs
    van den Berg, L.
    van den Berg, S. M.
    Martens, E. E. C. P.
    Hazewinkel, H. A. W.
    Dijkshoorn, N. A.
    Delemarre-van de Waal, H. A.
    Heutink, P.
    Leegwater, P. A. J.
    Heuven, H. C. M.
    ANIMAL GENETICS, 2010, 41 (05) : 557 - 557
  • [23] Renal changes in melanocortin-4 receptor deficient (MC4R (-/-)) that are severely obese but not hypertensive
    Tallam, LS
    Stec, DE
    daSilva, AA
    Hall, JE
    FASEB JOURNAL, 2005, 19 (05): : A1581 - A1581
  • [24] Melanocortin-4 receptor gene (MC4R) mutations in a large German epidemiological sample
    Hinney, A
    Bettecken, T
    Brumm, H
    Tarnow, P
    Reichwald, K
    Lichtner, P
    Scherag, A
    Vollmert, C
    Illig, T
    Wichmann, HE
    Schäfer, H
    Biebermann, H
    Platzer, M
    Meitinger, T
    Hebebrand, J
    OBESITY RESEARCH, 2005, 13 : A39 - A39
  • [25] Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying
    Seelig, Eleonora
    Henning, Elana
    Keogh, Julia M.
    Gillett, Daniel
    Shin, Evelyn
    Buscombe, John
    van der Klaauw, Agatha A.
    Farooqi, I. Sadaf
    CLINICAL ENDOCRINOLOGY, 2022, 96 (02) : 270 - 275
  • [26] Signal pathway analysis of selected obesity-associated melanocortin-4 receptor class V mutants
    Sharma, Sunita
    Thibodeau, Stephanie
    Lytton, Jonathan
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2020, 1866 (08):
  • [27] Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment
    Ayers, Kristin L.
    Glicksberg, Benjamin S.
    Garfield, Alastair S.
    Longerich, Simonne
    White, Joseph A.
    Yang, Pengwei
    Du, Lei
    Chittenden, Thomas W.
    Gulcher, Jeffery R.
    Roy, Sophie
    Fiedorek, Fred
    Gottesdiener, Keith
    Cohen, Sarah
    North, Kari E.
    Schadt, Eric E.
    Li, Shuyu D.
    Chen, Rong
    Van der Ploeg, Lex H. T.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (07): : 2601 - 2612
  • [28] Familial early-onset obesity in Turkish children: variants and polymorphisms in the melanocortin-4 receptor (MC4R) gene
    Kirmizibekmez, Heves
    Demirkol, Yasemin Kendir
    Dogan, Ozlem Akgun
    Seymen, Gulcan
    Balci, Elif Inan
    Atla, Pinar
    Dursun, Fatma
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2022, 35 (05): : 657 - 662
  • [29] Associations between obesity candidate gene polymorphisms (fat mass and obesity-associated (FTO), melanocortin-4 receptor (MC4R), leptin (LEP) and leptin receptor (LEPR)) and dietary intake in pregnant women
    Martins, Maisa C.
    Trujillo, Janet
    Freitas-Vilela, Ana Amelia
    Farias, Dayana R.
    Rosado, Eliane L.
    Struchiner, Claudio J.
    Kac, Gilberto
    BRITISH JOURNAL OF NUTRITION, 2018, 120 (04) : 454 - 463
  • [30] Rapid communication:: Linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene
    Kim, KS
    Larsen, NJ
    Rothschild, MF
    JOURNAL OF ANIMAL SCIENCE, 2000, 78 (03) : 791 - 792