Effect of berbamine on T-cell mediated immunity and the prevention of rejection on skin transplants in mice

被引：22
|
作者：
Luo, CN [1 ]
Lin, X
Li, WK
Pu, F
Wang, LW
Xie, SS
Xiao, PG
机构：
[1] Chinese Acad Med Sci, Inst Med Plant Dev, Dept Immunol, Peking Union Med Coll, Beijing 100094, Peoples R China
[2] Beijing Med Univ, Immunol Res Ctr, Beijing 100083, Peoples R China
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1998年 / 59卷 / 03期
关键词：
berbamine; allograft rejection; immunosuppressive;
D O I：
10.1016/S0378-8741(97)00117-7
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Berbamine, an ingredient of Berberis, which itself is widely utilized in Chinese folk-medicine has been used as a source of leukogenics, anti-arrhythmics and anti-hypertensives. In recent years, the immunosuppressive effects of berbamine has been demonstrated. In order to further investigate the value of berbamine as an immunosuppressive agent, the delayed type hypersensitivity reaction(DTH) response with sheep red blood cells (SRBC), the mixed lymphocyte reaction (MLR) and a skin model of allograft rejection on mice were studied. Berbamine showed suppressive effects on DTH and MLR and significantly prolonged allograft survival compared with untreated transplanted mice. The results indicate that berbamine may be a potential agent in clinical trasplantation. (C) 1998 Elsevier Science Ireland Ltd.
引用
收藏
页码：211 / 215
页数：5
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