Rhodium-catalyzed asymmetric hydrogenation of unprotected β-enamine phosphonates

被引：11

作者：

Zhou, Ming ^{[1
]}

Xue, Zejian ^{[1
]}

Cao, Min ^{[1
]}

Dong, Xiu-Qin ^{[1
]}

Zhang, Xumu ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 20期

基金：

中国国家自然科学基金;

关键词：

ALPHA-AMINO; AMINOPHOSPHONATES; INHIBITOR;

D O I：

10.1039/c6ob00540c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have successfully developed a strategy for the first time for the enantioselective Rh-TaniaPhos catalyzed asymmetric hydrogenation of unprotected beta-enamine phosphonates to free beta-amino phosphonates directly with good enantioselectivities (80%-86% ee) and high conversions (>99% conversion). The resulting chiral free beta-amino phosphonates and their derivatives are important intermediates in biochemistry and pharmaceuticals.

引用

页码：4582 / 4584

页数：3

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