p53 family interactions and yeast: together in anticancer therapy

被引：11

作者：

Gomes, Sara ^{[1
]}

Leao, Mariana ^{[1
]}

Raimundo, Liliana ^{[1
]}

Ramos, Helena ^{[1
]}

Soares, Joana ^{[1
]}

Saraiva, Lucilia ^{[1
]}

机构：

[1] Univ Porto, Dept Ciencias Biol, Microbiol Lab, UCIBIO REQUIMTE,Fac Farm, Rua Jorge Viterbo Ferreira 228, P-4050313 Oporto, Portugal

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 04期

关键词：

WILD-TYPE P53; MUTANT P53; FUNCTIONAL ASSAY; TRANSCRIPTIONAL ACTIVITY; P53-MDM2; INTERACTION; MDM2; ONCOPROTEIN; 2-HYBRID SYSTEM; CANCER-THERAPY; P73; FUNCTION; IN-VITRO;

D O I：

10.1016/j.drudis.2016.02.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The p53 family proteins are among the most appealing targets for cancer therapy. A deeper understanding of the complex interplay that these proteins establish with murine double minute (MDM)2, MDMX, and mutant p53 could reveal new exciting therapeutic opportunities in cancer treatment. Here, we summarize the most relevant advances in the biology of p53 family protein-protein interactions (PPIs), and the latest pharmacological developments achieved from targeting these interactions. We also highlight the remarkable contributions of yeast-based assays to this research. Collectively, we emphasize promising strategies, based on the inhibition of p53 family PPIs, which have expedited anticancer drug development.

引用

页码：616 / 624

页数：9

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