Facile discrimination of aldose enantiomers by reversed-phase HPLC

被引：765
|
作者：
Tanaka, Takashi
Nakashima, Tatsuya
Ueda, Toshihisa
Tomii, Kenji
Kouno, Isao
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan
[2] Saga Univ, Fac Agr, Saga 8400027, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 06期
关键词：
aldose; absolute configuration; HPLC; cysteine; isothiocyanate;
D O I：
10.1248/cpb.55.899
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One-pot reactions of aldoses with L-Cysteine methyl ester and o-tolyl isothiocyanate yielded methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbamoyl)-thiazolidine-4(R)-carboxylates. Direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses. The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor.
引用
收藏
页码：899 / 901
页数：3
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