Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand

被引：23
|
作者：
Ou, Zhize [1 ]
Qian, Yimeng [1 ]
Gao, Yunyan [1 ]
Wang, Yunqing [1 ]
Yang, Guoqiang [2 ]
Li, Yi [3 ]
Jiang, Kaiyue [1 ]
Wang, Xin [1 ]
机构：
[1] Northwestern Polytech Univ, Dept Appl Chem, Sch Sci, Key Lab Space Appl Phys & Chem,Minist Educ, Xian 710072, Peoples R China
[2] Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, Beijing 100190, Peoples R China
[3] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Conves & Optoelect Mat, Beijing 100190, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 43期
基金：
中国国家自然科学基金;
关键词：
TELOMERIC G-QUADRUPLEX; MYC G-QUADRUPLEX; SIDE-CHAINS; C-MYC; METAL-COMPLEXES; IN-VIVO; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; MOLECULAR DOCKING; INTERCALATION;
D O I：
10.1039/c6ra01441k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two novel metal complexes 2-3 (metal = Pd-II, Pt-II) have been synthesized by reacting the corresponding tolylterpyridine complexes and the 4-aminonaphthalimide derivative 1. The interactions of the complexes with duplex DNA and telomeric G-quadruplex DNA have been investigated by UV-Vis spectroscopy and fluorescence spectroscopy. The studies reveal that the complexes 2-3 possess high affinity and reasonable selectivity for telomeric G-quadruplex DNA over duplex DNA. Spectroscopic and molecular docking studies suggest that the complexes 2-3 interact with telomeric G-quadruplex DNA mainly through groove binding. The compounds 1-3 are emissive (Phi(em) > 0.22), making it possible to study the localization of 1-3 in A549 using fluorescence microscopy. The complexes 2-3 are mainly localized in nuclei, while 1 is localized in the nuclei and cytoplasmic region after 0.5 h incubation. The complex 3 inhibits A549 cells selectively over non-cancerous NIH3T3 cells, with higher antitumor activity than 1 and cisplatin.
引用
收藏
页码：36923 / 36931
页数：9
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