Using Cytokines to Treat Cervical Intraepithelial and Invasive Neoplasia

被引：2
|
作者：
Tirone, Nelson R.
Michelin, Marcia A. [2 ]
Murta, Eddie F. C. [1 ]
机构：
[1] Univ Fed Triangulo Mineiro, Discipline Gynecol & Obstet, Oncol Res Inst IPON, BR-38025440 Uberaba, MG, Brazil
[2] Univ Fed Triangulo Mineiro, Dept Immunol, IPON, BR-38025440 Uberaba, MG, Brazil
来源：
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY | 2010年 / 5卷 / 02期
关键词：
Interferon-alpha; interleukin-19; cervical intraepithelial neoplasia; invasive cancer; uterine cervix; PROTEIN-KINASE CK2; HPV E7 ONCOPROTEIN; INTERFERON-ALPHA; MESSENGER-RNA; CANCER; RECEPTOR; FUTURE; CELLS; PHOSPHORYLATION; MODULATION;
D O I：
10.2174/157489210790936225
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A big challenge for research today is the manipulation of the immune system in order to destroy the neoplastic cells of tumors different origins by using cytokines and other immunostimulants. Interferon-alpha (IFN-alpha) has been used clinically and has been shown to inhibit the proliferation of various cell types in vivo and in vitro. This cytokine has been widely used in the treatment of infectious and chronic degenerative diseases and cancer. In this review, we describe different patents covering the use of cytokines and peptides as therapies for cervical intraepithelial neoplasias and cervical cancer, paying special attention to the use of IFN-alpha.
引用
收藏
页码：165 / 169
页数：5
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