Late outcome after surgical and topical treatment for Aspergillus mediastinitis after heart transplantation

被引：0

作者：

Vogt, Paul R. ^{[1
,2
]}

Aser, Raed ^{[2
]}

Schmidlin, Daniel ^{[3
]}

Mohacsi, Paul ^{[4
]}

Berdat, Pascal A. ^{[1
]}

Went, Phillip ^{[5
]}

Flepp, Markus ^{[6
]}

Mestres, Carlos A. ^{[2
]}

机构：

[1] Klin Pk, Dept Cardiovasc Surg, Bellariastr 38, CH-8038 Zurich, Switzerland

[2] Univ Hosp Zurich, Dept Cardiovasc Surg, Zurich, Switzerland

[3] Klin Pk, Dept Anaesthesia & Intens Care, Zurich, Switzerland

[4] Klin Pk, Dept Cardiol, Zurich, Switzerland

[5] Kantonsspital Graubunden, Dept Pathol, Chur, Switzerland

[6] Klin Pk, Dept Infect Dis, Zurich, Switzerland

来源：

JOURNAL OF CARDIAC SURGERY | 2021年 / 36卷 / 07期

关键词：

Aspergillus fumigatus; fungal infection; heart transplant; mediastinitis; mycotic aneurysm; topical treatment; AMPHOTERICIN-B; VORICONAZOLE;

D O I：

10.1111/jocs.15544

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The 7-year long-term survival after Aspergillus fumigatus mediastinitis after heart transplantation, an uncommonly described condition, is herein reported. A 66-year-old male developed an infection with A. fumigatus covering the entire thoracic cavity with a fungal turf after orthotopic heart transplantation. Repeated surgical removal of infectious and necrotic tissue together with innovative topical treatment using voriconazole and chlorhexidine combined with systemic antifungal treatment, helped in controlling the infection. Definitive wound closure was achieved by standard sternal refixation and latissimus dorsi muscle flap plasty. Survival after A. fumigatus mediastinitis after heart transplantation was achieved with sequential debridement in combination with topical application of antifungal agents.

引用

页码：2558 / 2561

页数：4

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