Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro

被引：50
|
作者：
Du, Ruikun [1 ,2 ,3 ]
Cooper, Laura [4 ]
Chen, Zinuo [1 ]
Lee, Hyun [5 ]
Rong, Lijun [4 ]
Cui, Qinghua [1 ,2 ,3 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266122, Peoples R China
[4] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA
[5] Univ Illinois, Dept Pharmaceut Sci, Ctr Bimol Sci, Coll Pharm,Biophys Core Res Resources Ctr, Chicago, IL 60607 USA
来源：
ANTIVIRAL RESEARCH | 2021年 / 190卷
关键词：
SARS-CoV-2; Chebulagic acid; Punicalagin; 3CLpro; Allosteric inhibitor; COVALENT;
D O I：
10.1016/j.antiviral.2021.105075
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To date, there are limited therapeutic options available to fight this disease. Here we examined the inhibitory abilities of two broad-spectrum antiviral natural products chebulagic acid (CHLA) and punicalagin (PUG) against SARS-CoV-2 viral replication. Both CHLA and PUG reduced virus-induced plaque formation in Vero-E6 monolayer at noncytotoxic concentrations, by targeting the enzymatic activity of viral 3-chymotrypsin-like cysteine protease (3CL(pro)) as allosteric regulators. Our study demonstrates the potential use of CHLA and PUG as novel COVID-19 therapies.
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收藏
页数：7
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