A Bayesian semiparametric approach with change points for spatial ordinal data

被引:1
|
作者
Cai, Bo [1 ]
Lawson, Andrew B. [2 ]
McDermott, Suzanne [3 ]
Aelion, C. Marjorie [4 ]
机构
[1] Univ S Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA
[2] Med Univ S Carolina, Div Biostat & Epidemiol, Charleston, SC 29425 USA
[3] Univ S Carolina, Dept Family & Prevent Med, Columbia, SC 29208 USA
[4] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Amherst, MA 01003 USA
关键词
Bayesian semiparametric model; change point; intellectual disability; soil metal exposure; regression splines; EXPOSURE; MODELS; HEALTH; SOILS; URBAN; LEAD; AGE;
D O I
10.1177/0962280212463415
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
The change-point model has drawn much attention over the past few decades. It can accommodate the jump process, which allows for changes of the effects before and after the change point. Intellectual disability is a long-term disability that impacts performance in cognitive aspects of life and usually has its onset prior to birth. Among many potential causes, soil chemical exposures are associated with the risk of intellectual disability in children. Motivated by a study for soil metal effects on intellectual disability, we propose a Bayesian hierarchical spatial model with change points for spatial ordinal data to detect the unknown threshold effects. The spatial continuous latent variable underlying the spatial ordinal outcome is modeled by the multivariate Gaussian process, which captures spatial variation and is centered at the nonlinear mean. The mean function is modeled by using the penalized smoothing splines for some covariates with unknown change points and the linear regression for the others. Some identifiability constraints are used to define the latent variable. A simulation example is presented to evaluate the performance of the proposed approach with the competing models. A retrospective cohort study for intellectual disability in South Carolina is used as an illustration.
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页码:644 / 658
页数:15
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