Self-assembled gels formed by covalent-bond that is able to include drug

被引：6
|
作者：
Lee, Ji Ha [3 ]
Kim, Ka Young [1 ,2 ]
Jung, Jong Hwa [1 ,2 ]
机构：
[1] Gyeongsang Natl Univ, Dept Chem, Jinju 52828, South Korea
[2] Gyeongsang Natl Univ, Res Inst Nat Sci, Jinju 52828, South Korea
[3] Univ Kitakyushu, Dept Chem & Biochem, Kitakyushu, Fukuoka 8080135, Japan
来源：
EUROPEAN POLYMER JOURNAL | 2019年 / 118卷
关键词：
Calix[4]arene; Hydrazone reaction; Gel; Drug delivery system; SUPRAMOLECULAR GEL; ORGANOGELS; HYDROGELS;
D O I：
10.1016/j.eurpolymj.2019.05.055
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A mixture of the calix[4]arene including hydrazine and dipheniyl aldehyde at different positions formed gel in DMSO by the hydrazone reaction under acidic conditions. These organogels were transformed into hydrogels without shape change by solvent exchange. Interestingly, G' and G '' values of the hydrogels increased 80-275-fold due to the formation of a three-dimensional network structure by intermolecular hydrogen bonding interactions. Furthermore, we describes the gel containing the drug and the release of the drug in a simple manner through solvent exchange. This suggests applicability of new drug delivery system using gel.
引用
收藏
页码：280 / 285
页数：6
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