The combination of metformin and valproic acid induces synergistic apoptosis of prostate cancer cells via p53 activation and the intrinsic pathway

被引：0
|
作者：
Tran, Linh N. K.
Kichenadasse, Ganessan
Morel, Katherine L.
Sykes, Pamela J.
机构：
来源：
CANCER RESEARCH | 2017年 / 77卷
关键词：
D O I：
10.1158/1538-7445.AM2017-1062
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1062
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells
    Okura, T
    Nakamura, M
    Takata, Y
    Watanabe, S
    Kitami, Y
    Hiwada, K
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 407 (03) : 227 - 235
  • [42] Rapamycin induces p53-dependent apoptosis in human prostate cancer cells via PI3K pathway
    Numanoglu, S.
    Avci, C. Biray
    Yilmaz, S.
    Saydam, G.
    Gunduz, C.
    FEBS JOURNAL, 2007, 274 : 154 - 154
  • [43] Combination of Metformin and Dichloroacetate Inhibits Proliferation and Induce Intrinsic Pathway of Apoptosis in PC-3 Human Prostate Cancer Cells
    Kiliccioglu, Ilker
    Konac, Ece
    Albayrak, Gulsah
    Donmez, Cigdem
    Bilen, Cenk Y.
    GAZI MEDICAL JOURNAL, 2015, 26 (4A): : 212 - 214
  • [44] Diethylaminoethyl chitosan induces apoptosis in HeLa cells via activation of caspase-3 and p53 expression
    Lee, Sang-Hoon
    Ryu, BoMi
    Je, Jae-Young
    Kim, Se-Kwon
    CARBOHYDRATE POLYMERS, 2011, 84 (01) : 571 - 578
  • [45] Combination of metformin and paclitaxel suppresses proliferation and induces apoptosis of human prostate cancer cells via oxidative stress and targeting the mitochondria-dependent pathway
    Zhao, Yuwan
    Zeng, Xin
    Tang, Huancheng
    Ye, Dongcai
    Liu, Jianjun
    ONCOLOGY LETTERS, 2019, 17 (05) : 4277 - 4284
  • [46] Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells
    Zhang, Qingyu
    Ma, Sheng
    Liu, Bin
    Liu, Jie
    Zhu, Runzhi
    Li, Mingyi
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (01) : 469 - 474
  • [47] Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia
    E McCormack
    I Haaland
    G Venås
    R B Forthun
    S Huseby
    G Gausdal
    S Knappskog
    D R Micklem
    J B Lorens
    Ø Bruserud
    B T Gjertsen
    Leukemia, 2012, 26 : 910 - 917
  • [48] Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia
    McCormack, E.
    Haaland, I.
    Venas, G.
    Forthun, R. B.
    Huseby, S.
    Gausdal, G.
    Knappskog, S.
    Micklem, D. R.
    Lorens, J. B.
    Bruserud, O.
    Gjertsen, B. T.
    LEUKEMIA, 2012, 26 (05) : 910 - 917
  • [49] Brevifoliol ester induces apoptosis in prostate cancer cells by activation of caspase pathway
    Bhukya, Balakishan
    Fatima, Kaneez
    Nagar, Abhishek
    Lakshmi, Vijaya
    Dubey, Poornima
    Kumar, Shailesh
    Kumar, Yogesh
    Luqman, Suaib
    Chanda, Debabrata
    Tandon, Sudeep
    Shanker, Karuna
    Khan, Feroz
    Negi, Arvind S.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2020, 95 (01) : 150 - 161
  • [50] CHEMOTHERAPY-INDUCED APOPTOSIS IN PANCREATIC CANCER INVOLVES THE P53 FAMILY AND IS MEDIATED VIA THE EXTRINSIC AND THE INTRINSIC PATHWAY
    Gebhardt, Kristina
    Melcher, Eva-Maria
    Koch, Andreas F.
    Lorenz, Katjo
    Stremmel, Wolfgang
    Mueller, Martina
    HEPATOLOGY, 2009, 50 (04) : 628A - 628A
12345