HLA-DRA is associated with Parkinson's disease in Iranian population

被引：17

作者：

Jamshidi, J. ^{[1
]}

Movafagh, A. ^{[2
,3
]}

Emamalizadeh, B. ^{[2
]}

Bidoki, A. Zare ^{[4
,5
]}

Manafi, A. ^{[6
]}

Firouzabadi, S. Ghasemi ^{[7
]}

Shahidi, G-A. ^{[8
]}

Kazeminasab, S. ^{[7
]}

Petramfar, P. ^{[9
]}

Fazeli, A. ^{[2
]}

Motallebi, M. ^{[2
]}

Mortazavi-Tabatabaei, S. A. ^{[10
]}

Kowsari, A. ^{[11
]}

Jafarian, Z. ^{[7
]}

Darvish, H. ^{[2
]}

机构：

[1] Fasa Univ Med Sci, Dept Biochem, Fasa, Iran

[2] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Dept Med Genet, Pediat Neurol Res Ctr, Sch Med, Tehran, Iran

[4] Univ Tehran Med Sci, Mol Immunol Res Ctr, Childrens Med Ctr Hosp, Tehran, Iran

[5] Univ Tehran Med Sci, Dept Immunol, Sch Med, Tehran, Iran

[6] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran

[7] Univ Social Welf & Rehabil Sci, Genet Res Ctr, Tehran, Iran

[8] Iran Univ Med Sci, Movement Disorders Clin, Hazrat Rassol Hosp, Tehran, Iran

[9] Shiraz Univ Med Sci, Dept Neurol, Shiraz, Iran

[10] Shahid Beheshti Univ Med Sci, Prote Res Ctr, Tehran, Iran

[11] Golestan Univ Med Sci, Stem Cell Res Ctr, Gorgan, Iran

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2014年 / 41卷 / 06期

关键词：

GENOME-WIDE ASSOCIATION; LOCUS; RISK; IDENTIFICATION; RS3129882; VARIANTS; REGION;

D O I：

10.1111/iji.12151

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The rs3129882, a noncoding variant in HLA-DR, was found to be associated with Parkinson's disease (PD) using several genome-wide association studies. The aim of this replication study was to explore the relationship between this variant and PD in Iranian population. Genomic DNA was extracted from peripheral blood samples, and the rs3129882 SNP was genotyped using a PCR-RFLP method in 520 PD patients and 520 healthy Iranian controls. Significant differences were found in allele frequencies between patients and controls ((2)= 4.64, P=0.031). Under additive and dominant models, the association of the SNP with PD risk is significant, where the A allele was observed to be protective. The results suggest that rs3129882 polymorphism may be a risk factor for PD in Iranian. This is the first study reporting such an association in this population. More replication studies are needed to confirm this data.

引用

页码：508 / 511

页数：4

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