Novel azaandrostane derivatives for the synthesis of 17β-(N-tert-butyl carbamoyl)-4-aza-5α-androst-1-ene-3-one

被引：0

作者：

Rao, Divvela V. N. Srinivasa

Trinadhachari, Ganala Naga

Prabahar, Koilpillai Joseph

Dandala, Ramesh ^{[1
]}

Sivakumaran, Meenakshisundaram

Naidu, Andra

机构：

[1] APl Res Ctr, Dept Chem Res, Hyderabad 500072, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Hyderabad 500072, Andhra Pradesh, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 03期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new industrially viable process for the preparation of 17 beta-(N-tert-butyl carbamoyl)-4-aza-5 alpha-androst-1-ene-3-one, also known by the generic name finasteride (6) from the new azaandrostane derivatives such as 17 beta-(N-tert-butyl carbamoyl)-4-benzoyl-4-aza-5 alpha-andro stane-3-one (4), 17 beta-(N-tert-butyl carbamoyl)-4-benzoyl-4-aza-5 alpha-androst-1-ene-3-one (5) is reported. In this process, benzoyl group is demonstrated as a novel protecting group for lactamic NH group. The structures of newly prepared compounds were established on the basis of spectral data (IR, H-1-NMR, and MS).

引用

页码：663 / 667

页数：5

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