GSH-Depleted PtCu3 Nanocages for Chemodynamic- Enhanced Sonodynamic Cancer Therapy

被引：453

作者：

Zhong, Xiaoyan ^{[1
]}

Wang, Xianwen ^{[2
]}

Cheng, Liang ^{[2
]}

Tang, Yong'an ^{[3
]}

Zhan, Guiting ^{[1
]}

Gong, Fei ^{[2
]}

Zhang, Rui ^{[2
]}

Hu, Jun ^{[1
]}

Liu, Zhuang ^{[2
]}

Yang, Xiangliang ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Hubei, Peoples R China

[2] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China

[3] Shenzhen Univ, Collaborat Innovat Ctr Optoelect Sci & Technol, Key Lab Optoelect Devices & Syst, Coll Optoelect Engn,Minist Educ & Guangdong Prov, Shenzhen 518060, Guangdong, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2020年 / 30卷 / 04期

基金：

美国国家科学基金会;

关键词：

chemodynamic therapy; GSH depletion; nanozyme; PtCu3; nanocages; sonodynamic therapy; PHOTODYNAMIC THERAPY; GLUTATHIONE LEVELS; TUMOR; NANOPARTICLES; NANOCRYSTALS;

D O I：

10.1002/adfm.201907954

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)-based therapy, improving the outcome of chemodynamic therapy (CDT)-enhanced sonodynamic therapy (SDT) by depleting GSH is full of great challenge. Herein, PtCu3 nanocages are first reported as acting as a sonosensitizer with highly efficient ROS generation under ultrasound irradiation. In addition, PtCu3 nanocages can act as horseradish peroxidase-like nanozymes, catalyzing the decomposition of H2O2 into (OH)-O-center dot under acidic conditions for CDT. Surprisingly, PtCu3 nanocages can act as another kind of nanozyme, mimicking glutathione peroxidase (GSH-Px), which plays an important role in accelerating GSH depletion by oxidizing molecules, further weakening the capacity of tumor cells scavenging ROS by GSH. Both in vitro and in vivo studies demonstrate that PtCu3 nanocages perform well in reducing GSH level for CDT-enhanced SDT. Moreover, utilizing the high absorption in the near-infrared region and strong X-ray attenuation ability, the PtCu3 nanocages are able to conduct photoacoustic/computed tomography dual-modal imaging-guided combined cancer therapy. It is worth mentioning that PtCu3 nanocages cause minimal toxicity to normal tissues at therapeutic doses. This work highlights the use of PtCu3 nanocages for effective CDT-enhanced SDT via GSH depletion.

引用

页数：12