SYNTHESIS AND NEUROTROPIC ACTIVITY OF SUBSTITUTED 5-DIALKYLAMINOACETYL-3a,4,5,9b-TETRAYDRO-3H-CYCLOPENTA[c]QUINOLINES

被引：2

作者：

Krainova, G. F. ^{[1
]}

Vikharev, Yu. B. ^{[1
]}

Anikina, L. V. ^{[1
]}

Sivtseva, E. V. ^{[2
]}

Glushkov, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Tech Chem, Ural Branch, Perm, Russia

[2] Perm State Univ, Perm, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 11期

关键词：

quinolines; amides; Povarov reaction; analgesic activity; open-field test; POVAROV REACTION; CYCLOPENTADIENE;

D O I：

10.1007/s11094-010-0362-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted 5-dialkylaminoacetyl-3a, 4,5,9b-tetrahydro-3H-cyclopenta[c]quinolines were synthesized by amination of the corresponding 5-chloroacetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c] quinolines. The acute toxicity, analgesic activity, and influence of the obtained compounds on the locomotor and exploratory activity in the open-field test were studied.

引用

页码：606 / 609

页数：4

共 50 条

[11] 8-chloro-4-[1-(phenylsulfonyl)indol-3-yl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Sankaranarayanan, R
Yogavel, M
Velmurugan, D
Sekar, K
Babu, G
Perumal, PT
Raj, SSS
Fun, HK
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2003, 59 : O49 - O51
[12] SYNTHESIS AND DOPAMINERGIC ACTIVITY OF CIS-2,3,3A,4,5,9B-HEXAHYDRO-1-SUBSTITUTED-1H-BENZ[E]INDOLES AND TRANS-2,3,3A,4,5,9B-HEXAHYDRO-1-SUBSTITUTED-1H-BENZ[E]INDOLES
SONG, X
CRIDER, AM
KLEIN, C
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 135 - MEDI
[13] Synthesis and Neurotropic Activity of Amino Derivatives of Cyclopenta[4',5']pyrido[3',2':4,5]thieno[3,2-d ]pyrimidines and Pyrimido[4',5':4,5]thieno[2,3-c]isoquinolines
Paronikyan, E. G.
Dashyan, Sh. Sh.
Noravyan, A. S.
Dzhagatspanyan, I. A.
Paronikyan, R. G.
Nazaryan, I. M.
Akopyan, A. G.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2016, 50 (05) : 301 - 305
[14] Synthesis and Neurotropic Activity of Amino Derivatives of Cyclopenta[4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d ]pyrimidines and Pyrimido[4′,5′:4,5]thieno[2,3-c]isoquinolines
E. G. Paronikyan
Sh. Sh. Dashyan
A. S. Noravyan
I. A. Dzhagatspanyan
R. G. Paronikyan
I. M. Nazaryan
A. G. Akopyan
Pharmaceutical Chemistry Journal, 2016, 50 : 301 - 305
[15] Synthesis and crystal structure of 3-(4′-methoxyphenyl)- and 3-(4′-hydroxyphenyl)-1-amino-3a,4,5,9b-tetrahydro-9b-hydroxy-3H-cyclopenta[a]naphthalene-2-carbonitrile
Shi, DQ
Rong, LC
Wang, JX
Zhuang, QY
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2005, 25 (12) : 1560 - 1564
[16] A facile synthesis of novel [4-(aryl)3a,4,5,9b-tetrahydrocyclopenta[c]quinolin-8-ylmethyl]-8′-(4′-aryl)-3a′,4′,5′, 9b′-tetrahydro-3H-cyclopenta[c]quinolines:: Indium trichloride catalyzed intermolecular imino Diels-Alder reaction of cyclopentadiene with Schiff's bases
Nandagopal, S
Geetha, B
Perumal, PT
SYNTHETIC COMMUNICATIONS, 2004, 34 (06) : 1157 - 1161
[17] Synthesis and Anticonvulsive Activity of 7-Amino-Substituted Cyclopenta[4',5']-pyrido[3',2':4,5]furo[3,2-d]pyrimidines
Sirakanyan, S. N.
Ovakimyan, A. A.
Noravyan, A. S.
Dzhagatspanyan, I. A.
Shakhatuni, A. A.
Nazaryan, I. M.
Akopyan, A. G.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2013, 47 (03) : 130 - 134
[18] Synthesis and Anticonvulsive Activity of 7-Amino-Substituted Cyclopenta[4′,5′]-pyrido[3′,2′:4,5]furo[3,2-d]pyrimidines
S. N. Sirakanyan
A. A. Ovakimyan
A. S. Noravyan
I. A. Dzhagatspanyan
A. A. Shakhatuni
I. M. Nazaryan
A. G. Akopyan
Pharmaceutical Chemistry Journal, 2013, 47 : 130 - 134
[19] Synthesis of 3a, 4-dihydro-8-substituted-3H-isoxazolo [c-4,3] thiapyrano [5,6-3,2] quinolines
Prabhuswamy, B
Ambekar, SY
SYNTHETIC COMMUNICATIONS, 1999, 29 (20) : 3477 - 3485
[20] 2,3,3a,4,5,9b-hexahydro-4-phenylfuro-[3,2-c]quinoline
Ravikumar, K
Sridhar, B
Mahesh, M
Reddy, VVN
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O542 - O544

← 1 2 3 4 5 →