SYNTHESIS AND NEUROTROPIC ACTIVITY OF SUBSTITUTED 5-DIALKYLAMINOACETYL-3a,4,5,9b-TETRAYDRO-3H-CYCLOPENTA[c]QUINOLINES

被引：2
|
作者：
Krainova, G. F. [1 ]
Vikharev, Yu. B. [1 ]
Anikina, L. V. [1 ]
Sivtseva, E. V. [2 ]
Glushkov, V. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Tech Chem, Ural Branch, Perm, Russia
[2] Perm State Univ, Perm, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 11期
关键词：
quinolines; amides; Povarov reaction; analgesic activity; open-field test; POVAROV REACTION; CYCLOPENTADIENE;
D O I：
10.1007/s11094-010-0362-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of substituted 5-dialkylaminoacetyl-3a, 4,5,9b-tetrahydro-3H-cyclopenta[c]quinolines were synthesized by amination of the corresponding 5-chloroacetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c] quinolines. The acute toxicity, analgesic activity, and influence of the obtained compounds on the locomotor and exploratory activity in the open-field test were studied.
引用
收藏
页码：606 / 609
页数：4
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