Cephasinenoside A, a new cephalotane diterpenoid glucoside from Cephalotaxus sinensis

被引：27
|
作者：
Zhao, Chun-Xue [1 ,2 ]
Li, Bing-Qian [3 ]
Shao, Zhao-Xiang [1 ,2 ]
Li, Da-Hong [1 ,2 ]
Jing, Yong-Kui [3 ]
Li, Zhan-Lin [1 ,2 ]
Hua, Hui-Ming [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Med Mat, Box 49, Shenyang 110016, Liaoning, Peoples R China
[3] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Liaoning, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 43期
基金：
中国国家自然科学基金;
关键词：
Cephalotaxus sinensis; Cephalotane diterpenoid glucoside; Cephasinenoside A; Antiproliferative activity; TROPONE; HARRINGTONOLIDE; NORDITERPENOIDS; HAINANOLIDOL;
D O I：
10.1016/j.tetlet.2019.151154
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new cephalotane diterpenoid glucoside, cephasinenoside A (1), was isolated from the twigs and leaves of Cephalotaxus sinensis (Rehd. et Wils.) Li. The structure of 1 was established on the basis of spectroscopic analyses and ECD calculations. Compound 1 represents the first cephalotane diterpenoid glycoside which inhibits the proliferation of human acute myeloid leukemia HL-60 cells with a GI(50) value of 7.17 +/- 1.03 mu M. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：4
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