Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology

被引：25
|
作者：
Speck, Nicole E. [1 ]
Schuurmans, Mace M. [1 ]
Murer, Christian [1 ]
Benden, Christian [1 ]
Huber, Lars C. [1 ]
机构：
[1] Univ Zurich Hosp, Div Pulmonol, Ramistr 100, CH-8091 Zurich, Switzerland
来源：
RESPIRATORY RESEARCH | 2016年 / 17卷
关键词：
Blood; Bronchoalveolar lavage; Cytology; Diagnosis; Graft rejection; Lung transplantation; Plasma; BRONCHIOLITIS OBLITERANS SYNDROME; NATURAL-KILLER-CELLS; ACUTE CELLULAR REJECTION; TRANSBRONCHIAL BIOPSY SPECIMENS; TRANSPLANT RECIPIENTS; NK-CELLS; PULMONARY ALLOGRAFT; DENDRITIC CELLS; T-CELLS; B-CELL;
D O I：
10.1186/s12931-016-0391-y
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of the cell profiles of bronchoalveolar lavage and plasma samples during acute lung allograft rejection. The value of these cells and changes within the pattern of differential cytology to support the diagnosis of acute lung allograft rejection is discussed. Current findings on the topic are highlighted and trends for future research are identified.
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页数：12
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