Oxygen Self-Sufficient Nanoplatform for Enhanced and Selective Antibacterial Photodynamic Therapy against Anaerobe-Induced Periodontal Disease

被引:118
|
作者
Sun, Xiaolin [1 ]
Sun, Jiao [2 ]
Sun, Yue [1 ]
Li, Chunyan [3 ]
Fang, Jiao [1 ]
Zhang, Tianshou [3 ]
Wan, Yao [1 ]
Xu, Lin [4 ]
Zhou, Yanmin [1 ]
Wang, Lin [1 ]
Dong, Biao [4 ]
机构
[1] Jilin Univ, Sch Dent, Dept Oral Implantol, Changchun 130021, Peoples R China
[2] Jilin Univ, Norman Bethune Coll Med, Dept Cell Biol, Changchun 130021, Peoples R China
[3] Jilin Prov Key Lab Sci & Technol Stomatol Nanoeng, Changchun 130021, Peoples R China
[4] Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China
基金
中国博士后科学基金; 美国国家科学基金会;
关键词
antimicrobial photodynamic therapies; manganese dioxide; nanocomposites; oxygen generation; periodontal disease; selective killing;
D O I
10.1002/adfm.202101040
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The hypoxic microenvironment, continuous oxygen consumption, and poor excitation light penetration depth during antimicrobial photodynamic therapy (aPDT) tremendously hinder the effects on bacterial inactivation. Herein, a smart nanocomposite with oxygen-self-generation is presented for enhanced and selective antibacterial properties against anaerobe-induced periodontal diseases. By encapsulating Fe3O4 nanoparticles, Chlorin e6 and Coumarin 6 in the amphiphilic silane, combined light (red and infrared) stimulated aPDT is realized due to the increased conjugate structure, the corresponding red-shifted absorption, and the magnetic navigation performance. To address the hypoxic microenvironment problem, further modification of MnO2 nanolayer on the composites is carried out, and catalytical activity is involved for the decomposition of hydrogen peroxide produced in the metabolic processing, providing sufficient oxygen for aPDT in infection sites. Experiments in the cellular level and animal model proved that the rising oxygen content could effectively relieve the hypoxia in a periodontal pocket and enhance the ROS production, remarkably boosting aPDT efficacy. The increasing local level of oxygen also shows the selective inhibition of pathogenic and anaerobic bacteria, which determines the success of periodontitis treatment. Therefore, this finding is promising for combating anaerobic pathogens with enhanced and selective properties in periodontal diseases, even in other bacteria-induced infections, for future clinical application.
引用
收藏
页数:15
相关论文
共 40 条
  • [21] A catalase-loaded hierarchical zeolite as an implantable nanocapsule for ultrasound-guided oxygen self-sufficient photodynamic therapy against pancreatic cancer
    Hu, Dehong
    Chen, Zhuwen
    Sheng, Zonghai
    Gao, Duyang
    Yan, Fei
    Ma, Teng
    Zheng, Hairong
    Hong, Mei
    NANOSCALE, 2018, 10 (36) : 17283 - 17292
  • [22] An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors
    Yang, Guoliang
    Tian, Jia
    Chen, Chao
    Jiang, Dawei
    Xue, Yudong
    Wang, Chaochao
    Gao, Yun
    Zhang, Weian
    CHEMICAL SCIENCE, 2019, 10 (22) : 5766 - 5772
  • [23] A H2O2 self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy
    Zhang, Shichao
    Cao, Changyu
    Lv, Xinyi
    Dai, Hanming
    Zhong, Zhihao
    Liang, Chen
    Wang, Wenjun
    Huang, Wei
    Song, Xuejiao
    Dong, Xiaochen
    CHEMICAL SCIENCE, 2020, 11 (07) : 1926 - 1934
  • [24] Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy
    Luo, Zhenyu
    Zheng, Mingbin
    Zhao, Pengfei
    Chen, Ze
    Siu, Fungming
    Gong, Ping
    Gao, Guanhui
    Sheng, Zonghai
    Zheng, Cuifang
    Ma, Yifan
    Cai, Lintao
    SCIENTIFIC REPORTS, 2016, 6
  • [25] Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy
    Zhenyu Luo
    Mingbin Zheng
    Pengfei Zhao
    Ze Chen
    Fungming Siu
    Ping Gong
    Guanhui Gao
    Zonghai Sheng
    Cuifang Zheng
    Yifan Ma
    Lintao Cai
    Scientific Reports, 6
  • [26] Dual-action nanoplatform with a synergetic strategy to promote oxygen accumulation for enhanced photodynamic therapy against hypoxic tumors
    Ren, Chunling
    Xu, Xiao
    Yan, Dan
    Gu, Mengzhen
    Zhang, Jinghan
    Zhang, Haili
    Han, Chao
    Kong, Lingyi
    ACTA BIOMATERIALIA, 2022, 146 : 465 - 477
  • [27] Mitochondria-Targeting and Oxygen Self-Supplying Eccentric Hollow Nanoplatform for Enhanced Breast Cancer Photodynamic Therapy
    Li, Jing
    Wang, Yu
    Tao, Jun
    Su, Xiaodan
    Zhu, Feipeng
    Lu, Wei
    Han, Xiaolin
    Dang, Meng
    Weng, Lixing
    BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2024, 2024
  • [28] Ruthenium(II) complexes coordinated to graphitic carbon nitride: Oxygen self-sufficient photosensitizers which produce multiple ROS for photodynamic therapy in hypoxia
    Wei, Fangmian
    Kuang, Shi
    Rees, Thomas W.
    Liao, Xinxing
    Liu, Jiangping
    Luo, Diqing
    Wang, Jinquan
    Zhang, Xiting
    Ji, Liangnian
    Chao, Hui
    BIOMATERIALS, 2021, 276
  • [29] Bonsai-inspired AIE nanohybrid photosensitizer based on vermiculite nanosheets for ferroptosis-assisted oxygen self-sufficient photodynamic cancer therapy
    Yu, Xinghua
    Zhang, Ying-Chuan
    Yang, Xing
    Huang, Ziyang
    Zhang, Tianfu
    Yang, Liusi
    Meng, Wenjing
    Liu, Xiaotong
    Gong, Ping
    Forni, Alessandra
    Zheng, Zheng
    Liu, Bilu
    Zhang, Pengfei
    Cai, Lintao
    Tang, Ben Zhong
    NANO TODAY, 2022, 44
  • [30] A MnO2-coated multivariate porphyrinic metal-organic framework for oxygen self-sufficient chemo-photodynamic synergistic therapy
    Zhu, Dan
    Wang, Bin
    Zhu, Xiao-Hua
    Zhu, Hai-Liang
    Ren, Shen-Zhen
    NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2021, 37