Biological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitors

被引：1
|
作者：
Guney, Murat [1 ]
Ekinci, Deniz [2 ]
Cavdar, Huseyin [3 ]
Senturk, Murat [1 ]
Zilbeyaz, Kani [1 ]
机构：
[1] Ibrahim Cecen Univ Agri, Sci & Art Fac, Dept Chem, Agri, Turkey
[2] Ondokuz Mayis Univ, Fac Agr, Agr Biotechnol Dept, Samsun, Turkey
[3] Dumlupinar Univ, Fac Educ, Kutahya, Turkey
来源：
INTERNATIONAL CONFERENCE ON ADVANCES IN NATURAL AND APPLIED SCIENCES: ICANAS 2016 | 2016年 / 1726卷
关键词：
IN-VITRO; DESIGN;
D O I：
10.1063/1.4945930
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Discovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some uracil derivatives (UDCs) (1-4) were reported. Some commercially available molecules (5-6) were also tested for comparison reasons. The novel UDCs were obtained in high yields using simple chemical procedures and exhibited much potent inhibitory activities against GR at low nanomolar concentrations with IC50 values ranging from 2.68 to 166.6 nM as compared with well-known agents.
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页数：3
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