Biological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitors

被引：1

作者：

Guney, Murat ^{[1
]}

Ekinci, Deniz ^{[2
]}

Cavdar, Huseyin ^{[3
]}

Senturk, Murat ^{[1
]}

Zilbeyaz, Kani ^{[1
]}

机构：

[1] Ibrahim Cecen Univ Agri, Sci & Art Fac, Dept Chem, Agri, Turkey

[2] Ondokuz Mayis Univ, Fac Agr, Agr Biotechnol Dept, Samsun, Turkey

[3] Dumlupinar Univ, Fac Educ, Kutahya, Turkey

来源：

INTERNATIONAL CONFERENCE ON ADVANCES IN NATURAL AND APPLIED SCIENCES: ICANAS 2016 | 2016年 / 1726卷

关键词：

IN-VITRO; DESIGN;

D O I：

10.1063/1.4945930

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Discovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some uracil derivatives (UDCs) (1-4) were reported. Some commercially available molecules (5-6) were also tested for comparison reasons. The novel UDCs were obtained in high yields using simple chemical procedures and exhibited much potent inhibitory activities against GR at low nanomolar concentrations with IC50 values ranging from 2.68 to 166.6 nM as compared with well-known agents.

引用

页数：3

共 50 条

[1] Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors
Cakmak, Resit
Durdagi, Serdar
Ekinci, Deniz
Senturk, Murat
Topal, Giray
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (18) : 5398 - 5402
[2] Investigation of Some Uracil Derivatives on Glutathione Reductase, Carbonic Anhydrase I and II Enzymes
Cavusoglu, Kubra
Senturk, Murat
ACTA PHYSIOLOGICA, 2017, 221 : 125 - 125
[3] Synthesis and Biological Evaluation of Novel Uracil Derivatives as Thymidylate Synthase Inhibitors
Lone, Mohammad Nadeem
Gul, Shazia
Mehraj, Umar
Sofi, Shazia
Dar, Abid Hamid
Ganie, Shabir Ahmad
Wani, Nissar Ahmad
Mir, Manzoor Ahmad
Zargar, Mohammed A. A.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2023, 19 (10) : 6212 - 6231
[4] Synthesis and Biological Evaluation of Novel Uracil Derivatives as Thymidylate Synthase Inhibitors
Mohammad Nadeem Lone
Shazia Gul
Umar Mehraj
Shazia Sofi
Abid Hamid Dar
Shabir Ahmad Ganie
Nissar Ahmad Wani
Manzoor Ahmad Mir
Mohammed A. Zargar
Applied Biochemistry and Biotechnology, 2023, 195 : 6212 - 6231
[5] Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors
Mentese, Emre
Yilmaz, Fatih
Emirik, Mustafa
Ulker, Serdar
Kahveci, Bahittin
BIOORGANIC CHEMISTRY, 2018, 76 : 478 - 486
[6] Benzenesulfonamide derivatives as potent acetylcholinesterase, α-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking studies
Taslimi, Parham
Isik, Mesut
Turkan, Fikret
Durgun, Mustafa
Turkes, Cuneyt
Gulcin, Ilhami
Beydemir, Sukru
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2021, 39 (15): : 5449 - 5460
[7] Synthesis and Biological Evaluation of Gem-Difluoromethylenated Statin Derivatives as Highly Potent HMG-CoA Reductase Inhibitors
Zhao, Zhao
Cui, Jiaxin
Yin, Yan
Zhang, Heng
Liu, Yecheng
Zeng, Rui
Fang, Chao
Kai, Zhenpeng
Wang, Zhonghua
Wu, Fanhong
CHINESE JOURNAL OF CHEMISTRY, 2016, 34 (08) : 801 - 808
[8] Biological evaluation of some tetrazole derivatives as cholinesterase inhibitors
Abu Mohsen, Usama
Yurttas, Leyla
Ozdemir, Ahmet
Turan-Zitouni, Gulhan
Kaplancikli, Zafer Asim
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, 2014, 4 (01): : 1 - 4
[9] Synthesis and biological evaluation of geniposide derivatives as potent and selective PTPlB inhibitors
Lei, Shuwen
Zhang, Dongdong
Qi, Yunyue
Chowdhury, Sharmin Reza
Sun, Ran
Wang, Juntao
Du, Yi
Fu, Lei
Jiang, Faqin
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 205
[10] Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors
Ji, Dezhong
Zhang, Wanwan
Xu, Yungen
Zhang, Jing-Jing
BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 28 (06)

← 1 2 3 4 5 →