THE TIGIT/CD226/CD155 AXIS AND THE EFFECTS OF COMBINING PD-1/PD-L1 BLOCKADE WITH TIGIT-TARGETING ANTIBODY THERAPY IN SYNGENEIC MURINE GLIOBLASTOMA MODELS

被引:1
|
作者
Gokhale, Prafulla [1 ]
Iorgulescu, Bryan [1 ]
Klapholz, Max [2 ]
Poitras, Michael [1 ]
Eschle, Benjamin [1 ]
Freeman, Gordon [1 ]
Anderson, Ana [3 ]
Reardon, David [1 ]
机构
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
[2] Univ Penn, Philadelphia, PA 19104 USA
[3] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
关键词
D O I
10.1136/jitc-2021-SITC2021.256
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
256
引用
收藏
页码:A277 / A278
页数:2
相关论文
共 50 条
  • [31] Functional systemic CD4 immunity is required for clinical responses to PD-L1/PD-1 blockade therapy
    Zuazo, Miren
    Arasanz, Hugo
    Fernandez-Hinojal, Gonzalo
    Jesus Garcia-Granda, Maria
    Gato, Maria
    Bocanegra, Ana
    Martinez, Maite
    Hernandez, Berta
    Teijeira, Lucia
    Morilla, Idoia
    Jose Lecumberri, Maria
    Fernandez de Lascoiti, Angela
    Vera, Ruth
    Kochan, Grazyna
    Escors, David
    EMBO MOLECULAR MEDICINE, 2019, 11 (07)
  • [32] Anti-PD-1 therapy reverses TIGIT+CD226+NK depletion in immunotherapy resistance of hepatocellular carcinoma through PVR/TIGIT pathway
    Wang, Jing
    Yang, Lin
    Wang, Han-xuan
    Cui, Song-ping
    Gao, Ya
    Hu, Bin
    Zhou, Lin
    Lang, Ren
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 130
  • [33] DNAM-1/Tigit/CD155/CD112 Axis Is a Novel Target of NK-Cell Therapy in Acute Myeloid Leukemia
    Kaito, Yuta
    Sugimoto, Emi
    Nakamura, Fumi
    Tsukune, Yutaka
    Sasaki, Makoto
    Yui, Shunsuke
    Yamaguchi, Hiroki
    Goyama, Susumu
    Nannya, Yasuhito
    Mitani, Kinuko
    Tamura, Hideto
    Imai, Yoichi
    BLOOD, 2022, 140 : 4514 - 4516
  • [34] Publisher Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells
    Xiangnan Guan
    Ruozhen Hu
    Yoonha Choi
    Shyam Srivats
    Barzin Y. Nabet
    John Silva
    Lisa McGinnis
    Robert Hendricks
    Katherine Nutsch
    Karl L. Banta
    Ellen Duong
    Alexis Dunkle
    Patrick S. Chang
    Chia-Jung Han
    Stephanie Mittman
    Nandini Molden
    Pallavi Daggumati
    Wendy Connolly
    Melissa Johnson
    Delvys Rodriguez Abreu
    Byoung Chul Cho
    Antoine Italiano
    Ignacio Gil-Bazo
    Enriqueta Felip
    Ira Mellman
    Sanjeev Mariathasan
    David S. Shames
    Raymond Meng
    Eugene Y. Chiang
    Robert J. Johnston
    Namrata S. Patil
    Nature, 2024, 627 (8005) : E11 - E11
  • [35] Targeting PD-L1 and TIGIT could restore intratumoral CD8 T cell function in human colorectal cancer
    Thibaudin, Marion
    Limagne, Emeric
    Hampe, Lea
    Ballot, Elise
    Truntzer, Caroline
    Ghiringhelli, Francois
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022, 71 (10) : 2549 - 2563
  • [36] LIGHT (TNFSF14) Costimulation Enhances Myeloid Cell Activation and Antitumor Immunity in the Setting of PD-1/PD-L1 and TIGIT Checkpoint Blockade
    Yoo, Kyung Jin
    Johannes, Kellsey
    Gonzalez, Louis E.
    Patel, Arpita
    Shuptrine, Casey W.
    Opheim, Zachary
    Lenz, Karen
    Campbell, Kristen
    Thuy-Ai Nguyen
    Miriyala, Jayalakshmi
    Smith, Connor
    McGuire, Ashlyn
    Tsai, Yi-Hsuan
    Rangwala, Fatima
    de Silva, Suresh
    Schreiber, Taylor H.
    Fromm, George
    JOURNAL OF IMMUNOLOGY, 2022, 209 (03): : 510 - 525
  • [37] Targeting PD-L1 and TIGIT could restore intratumoral CD8 T cell function in human colorectal cancer
    Marion Thibaudin
    Emeric Limagne
    Léa Hampe
    Elise Ballot
    Caroline Truntzer
    Francois Ghiringhelli
    Cancer Immunology, Immunotherapy, 2022, 71 : 2549 - 2563
  • [38] The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation
    Fan, Ji-wen
    Fan, Yu
    Wan, Zheng-li
    Yan, Lin
    Li, Ya-mei
    Bai, Yang-juan
    Wang, Lan-lan
    Chen, Jie
    Li, Yi
    JOURNAL OF IMMUNOLOGY RESEARCH, 2022, 2022
  • [39] The role of in vivo PD-1/PD-L1 interactions in syngeneic and allogeneic antitumor responses in murine tumor models.
    Zuberek, K
    Runyon, K
    Collins, M
    Leonard, JP
    Dunussi-Joannopoulos, K
    BLOOD, 2001, 98 (11) : 42B - 42B
  • [40] PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy
    Simon, Sylvain
    Voillet, Valentin
    Vignard, Virginie
    Wu, Zhong
    Dabrowski, Camille
    Jouand, Nicolas
    Beauvais, Tiffany
    Khammari, Amir
    Braudeau, Cecile
    Josien, Regis
    Adotevi, Olivier
    Laheurte, Caroline
    Aubin, Francois
    Nardin, Charles
    Rulli, Samuel
    Gottardo, Raphael
    Ramchurren, Nirasha
    Cheever, Martin
    Fling, Steven P.
    Church, Candice D.
    Nghiem, Paul
    Dreno, Brigitte
    Riddell, Stanley R.
    Labarriere, Nathalie
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (02)