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Sun Yat Sen Univ, Guangdong Prov Key Lab Diag & Treatment Major Neur, Natl Key Clin Dept & Key Discipline Neurol, Affiliated Hosp 1,Dept Neurol, Guangzhou 510080, Peoples R China Sun Yat Sen Univ, Guangdong Prov Key Lab Diag & Treatment Major Neur, Natl Key Clin Dept & Key Discipline Neurol, Affiliated Hosp 1,Dept Neurol, Guangzhou 510080, Peoples R China