Base pair stacking in nucleosome DNA and bendability sequence pattern

被引：19
|
作者：
Trifonov, Edward N. [1 ,2 ]
机构：
[1] Univ Haifa, Genome Divers Ctr, Inst Evolut, IL-31905 Haifa, Israel
[2] Masaryk Univ, Div Funct Genom & Prote, Fac Sci, CZ-62500 Brno, Czech Republic
来源：
JOURNAL OF THEORETICAL BIOLOGY | 2010年 / 263卷 / 03期
基金：
以色列科学基金会;
关键词：
Chromatin; Chromatin code; DNA deformation; DNA minor grooves; Nucleosome DNA sequence; Nucleosome positioning; NUCLEOTIDE-SEQUENCE; CHROMATIN DNA; FLEXIBILITY; ELEGANS; CORE;
D O I：
10.1016/j.jtbi.2009.11.020
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
DNA deformation in the nucleosome involves partial unstacking between bases and base pairs. By adjusting orientations of different base-pair stacks relative to the histone octamer surface, the optimal set of stacks and their positions is derived, resulting in a sequence pattern, theoretically best suitable for nucleosome DNA. The sequence is very much consistent with available experimental data, thus, suggesting a common eukaryotic nucleosome DNA bendability sequence pattern based exclusively on the very basics of DNA. (C) 2009 Elsevier Ltd. All rights reserved.
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页码：337 / 339
页数：3
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