Replication stress: getting back on track

被引：184
|
作者：
Berti, Matteo [1 ]
Vindigni, Alessandro [1 ]
机构：
[1] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 02期
基金：
美国国家卫生研究院;
关键词：
S-PHASE CHECKPOINT; DNA-DAMAGE TOLERANCE; FORK REVERSAL; MCM2-7; HELICASE; LEADING-STRAND; RESTART; REPAIR; REGRESSION; REPLISOME; TRANSLOCASE;
D O I：
10.1038/nsmb.3163
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful transmission of genetic information to daughter cells. Multiple replication stress-response pathways have been identified in recent years, thus raising questions about the specific and possibly redundant functions of these pathways. Here, we review the emerging mechanisms of the replication-stress response in mammalian cells and consider how they may influence the dynamics of the core DNA replication complex.
引用
收藏
页码：103 / 109
页数：7
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