Pyrrolizidine alkaloids

被引:137
|
作者
Robertson, Jeremy [1 ]
Stevens, Kiri [1 ]
机构
[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England
关键词
1ST TOTAL-SYNTHESIS; LANOSTEROL SYNTHASE INHIBITORS; ASYMMETRIC TOTAL-SYNTHESIS; NONCHIRAL-POOL SYNTHESIS; FORMAL 3+2 ANNULATION; POLYHYDROXYLATED PYRROLIZIDINES; STEREOSELECTIVE-SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; CONCISE SYNTHESIS; EFFICIENT SYNTHESIS;
D O I
10.1039/c4np00055b
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review covers pyrrolizidine alkaloids isolated from natural sources. Topics include: aspects of structure, isolation, and biological/pharmacological studies; total syntheses of necic acids, necine bases and closely-related non-natural analogues.
引用
收藏
页码:1721 / 1788
页数:68
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