Iodine as novel reagent for the 1,2-addition of trimethylsilyl cyanide to ketones including α,β-unsaturated ketones

被引：96

作者：

Yadav, JS ^{[1
]}

Reddy, BVS ^{[1
]}

Reddy, MS ^{[1
]}

Prasad, AR ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 52期

关键词：

ketones; trimethylsiyl cyanide; iodine; alpha-cyanohydrins;

D O I：

10.1016/S0040-4039(02)02321-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Molecular iodine is found to catalyze efficiently the addition of trimethylsilyl cyanide to a range of simple and functionalized ketones under very mild and convenient conditions to afford the corresponding cyanohydrin trimethylsilyl ethers in excellent yields in a short reaction period with high selectivity. a,P-Unsaturated ketones selectively afford the corresponding 1,2-adducts without the formation of 1,4-adducts under similar reaction conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：9703 / 9706

页数：4

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