Nickel/Photoredox-Catalyzed Enantioselective Reductive Cross-Coupling between Vinyl Bromides and Benzyl Chlorides

被引：13

作者：

Lu, Qianqian ^{[1
]}

Guan, Haixing ^{[1
,2
]}

Wang, Yan-En ^{[3
]}

Xiong, Dan ^{[1
]}

Lin, Tingzhi ^{[1
]}

Xue, Fei ^{[2
]}

Mao, Jianyou ^{[1
]}

机构：

[1] Nanjing Tech Univ, Sch Chem & Mol Engn, Inst Adv Synth, Tech Inst Fluorochem TIF, Nanjing 211816, Peoples R China

[2] Nanjing Forestry Univ, Inst Mat Phys & Chem, Coll Sci, Nanjing 210037, Peoples R China

[3] Hebei Agr Univ, Coll Sci, Baoding 071000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 12期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC SUZUKI-MIYAURA; ALPHA-BROMO ESTERS; ARYL BROMIDES; NEGISHI ARYLATIONS; NICKEL; HALIDES; MECHANISMS; LIGHT;

D O I：

10.1021/acs.joc.2c00707

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A visible-light-promoted nickel/photoredox-catalyzed reductive cross-coupling reaction between vinyl bromides and benzyl chlorides is reported. A diverse array of enantioenriched allylic centers containing products could be achieved in good yields (up to 90%) and high enantioselectivities (up to 95% ee). The mechanistic studies show that this reductive cross-coupling involves a radical pathway.

引用

页码：8048 / 8058

页数：11

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