Thrombolysis in Right versus Left Hemispheric Stroke

被引:6
|
作者
Blondin, Nicholas A. [2 ]
Staff, Ilene [3 ]
Lee, Nora [4 ]
McCullough, Louise D. [1 ,4 ]
机构
[1] Univ Connecticut, Ctr Hlth, Sch Med, Farmington, CT 06030 USA
[2] Univ Connecticut, Dept Med Educ, Sch Med, Farmington, CT 06030 USA
[3] Hartford Hosp, Res Program, Hartford, CT USA
[4] Hartford Hosp Stroke Ctr, Dept Neurol, Hartford, CT USA
来源
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2010年 / 19卷 / 04期
关键词
Stroke; hemisphere; functional laterality; tissue plasminogen activator; TISSUE-PLASMINOGEN ACTIVATOR; ACUTE ISCHEMIC-STROKE; SCALE; DIFFERENCE;
D O I
10.1016/j.jstrokecerebrovasdis.2009.04.012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Recent evidence has suggested that patients with right hemispheric stroke (RHS) present later to an emergency department, have a lower chance to receive intravenous (IV) recombinant tissue plasminogen activator (t-PA), and have poorer clinical outcomes than do patients with left hemispheric stroke (LHS). Methods: We analyzed the rate of IV t-PA administration with respect to the side of the affected hemisphere in a large community population, to determine whether a difference exists. The study population was a large prospective cohort of patients with acute stroke treated with IV t-PA at our hospital's stroke center (October 2000 to October 2006). Results: Of 2932 patients presenting with ischemic stroke, 953 met criteria for study inclusion. In all, 151 patients received IV t-PA. Between groups, there was no significant difference in presentation within 3 hours after acute stroke (P = .180). There was no difference in the use of IV t-PA between patients with RHS and LHS (P = .237). Conclusions: There was no difference with respect to affected hemisphere in time to presentation to the emergency department. Furthermore, there was no difference in the rate of IV t-PA administration for patients with RHS versus LHS. This finding is in contrast to previous research on IV t-PA use in hemispheric stroke and may reflect improved recognition of right hemispheric syndromes.
引用
收藏
页码:269 / 272
页数:4
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