COPD and the microbiome

被引:127
|
作者
Mammen, Manoj J. [1 ,2 ,3 ,4 ]
Sethi, Sanjay [1 ,2 ,3 ,5 ]
机构
[1] SUNY Buffalo, Sch Med, Div Pulm, Buffalo, NY 14260 USA
[2] SUNY Buffalo, Sch Med, Div Crit Care, Buffalo, NY 14260 USA
[3] SUNY Buffalo, Sch Med, Div Sleep Med, Buffalo, NY 14260 USA
[4] SUNY Buffalo, Sch Med, Dept Biomed Informat, Buffalo, NY 14260 USA
[5] Vet Affairs Western New York Healthcare Syst, Buffalo, NY USA
关键词
16S Ribosomal RNA; 16S rRNA gene sequencing; chronic obstructive pulmonary disease; microbiome; OBSTRUCTIVE PULMONARY-DISEASE; RESPIRATORY MICROBIOME; BRONCHIAL MICROBIOME; AIRWAY INFLAMMATION; BACTERIA; EXACERBATIONS; INFECTION; COMMUNITIES; ORGANISMS;
D O I
10.1111/resp.12732
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Traditional culture techniques confirm that bacteria have an important role in Chronic Obstructive Pulmonary Disease (COPD). In individuals with COPD, acquisition of novel bacterial strains is associated with onset of acute exacerbation of COPD, which leads to further lung dysfunction and enormous health-care costs. Recent study of the human microbiome, the total composite of the bacteria on the human body, posited the microbiome as the last human organ studied, as the microbiome performs a multitude of metabolic functions absent in the human genome. The largest project to study the human microbiome was the National Institutes of Health (NIH) human microbiome project (HMP) started in 2007 to understand the normal' microbiome. However due to the presumption that the healthy human lung was sterile, the respiratory tract was not included in that study. The advent of next-generation sequencing technologies has allowed the investigation of the human respiratory microbiome, which revealed that the healthy lung does have a robust microbiome. Subsequent studies in individuals with COPD revealed that the microbiome composition fluctuates with severity of COPD, composition of the individual aero-digestive tract microbiomes, age, during an acute exacerbation of COPD and with the use of steroids and/or antibiotics. Understanding the impact of the microbiome on COPD progression and risk of exacerbation will lead to directed therapies for prevention of COPD progression and exacerbation.
引用
收藏
页码:590 / 599
页数:10
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