Neurotensin: A role in substance use disorder?

被引：35
|
作者：
Ferraro, Luca [1 ,2 ]
Fasiolo, Laura Tiozzo [1 ]
Beggiato, Sarah [3 ]
Borelli, Andrea C. [3 ]
Pomierny-Chamiolo, Lucyna [4 ]
Frankowska, Malgorzata [5 ]
Antonelli, Tiziana [3 ]
Tomasini, Maria C. [1 ]
Fuxe, Kjell [3 ]
Filip, Malgorzata [5 ]
机构：
[1] Univ Ferrara, Dept Life Sci & Biotechnol, Via Fossato di Mortara 17-19, I-44121 Ferrara, Italy
[2] Univ Ferrara, Lab Technol Adv Therapies LTTA, I-44121 Ferrara, Italy
[3] Univ Ferrara, Dept Med Sci, I-44121 Ferrara, Italy
[4] Jagiellonian Univ, Coll Med, Dept Toxicol, Krakow, Poland
[5] Polish Acad Sci, Inst Pharmacol, Lab Drug Addict Pharmacol, Krakow, Poland
来源：
JOURNAL OF PSYCHOPHARMACOLOGY | 2016年 / 30卷 / 02期
基金：
瑞典研究理事会;
关键词：
Agonist; antagonist; behavioral sensitization; conditioned place preference; drug abuse; drug self-administration; hyperlocomotion; neurotensin; neurotensin receptor; preclinical research; review; VENTRAL TEGMENTAL AREA; RECEPTOR-RECEPTOR INTERACTIONS; QUINPIROLE-INDUCED INHIBITION; NUCLEUS-ACCUMBENS SHELL; CENTRAL-NERVOUS-SYSTEM; ENDOGENOUS NEUROTENSIN; BEHAVIORAL SENSITIZATION; PREFRONTAL CORTEX; MIDBRAIN DOPAMINE; PLACE PREFERENCE;
D O I：
10.1177/0269881115622240
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Neurotensin is a tridecapeptide originally identified in extracts of bovine hypothalamus. This peptide has a close anatomical and functional relationship with the mesocorticolimbic and nigrostriatal dopamine system. Neural circuits containing neurotensin were originally proposed to play a role in the mechanism of action of antipsychotic agents. Additionally, neurotensin-containing pathways were demonstrated to mediate some of the rewarding and/or sensitizing properties of drugs of abuse. This review attempts to contribute to the understanding of the role of neurotensin and its receptors in drug abuse. In particular, we will summarize the potential relevance of neurotensin, its related compounds and neurotensin receptors in substance use disorders, with a focus on the preclinical research.
引用
收藏
页码：112 / 127
页数：16
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