CHARACTERISTICS OF MODERN PANCREATIC INFECTION AND THEIR SIGNIFICANCE IN SUBSTANTIATING ANTIBIOTIC THERAPY IN ACUTE PANCREATITIS

In order to find out the characteristics of modern pancreatic infection at 44 patients with acute pancreatitis on the first stage of the work were performed 147 bacteriological studies of the material - the content of peripancreatsc fluid and fragments of necrotic tissue of the pancreas and retroperitoneal tissue. It was stated that pancreatic infection was represented by a microflora with dominance of aerobic bacteria in the form of monoculture (37%) and aerobic-anaerobic associations (39%) with gram negative charater (56%), different pathogenicity of bacteria to pathomorphological substrates and invariability of existing associations in 57 % of patients. Sensitivity of pancreatic infection to different groups of antibiotics is established. On the second stage of the study, 460 patients with acute pancreatitis evaluated the efficacy and determined the feasibility of implementing various regimens of antibiotic therapy, in particular preventive, which contributed to the preservation of aseptic inflammatory process in 68% of observations and etiotropic - with the indigenous polyresistance microflora.