Guardian of Genetic Messenger-RNA-Binding Proteins

被引：14

作者：

Anji, Antje ^{[1
]}

Kumari, Meena ^{[1
]}

机构：

[1] Kansas State Univ, Coll Vet Med, Dept Anat & Physiol, Manhattan, KS 66506 USA

来源：

BIOMOLECULES | 2016年 / 6卷 / 01期

关键词：

alcohol; gene expression; RNA-binding proteins; mRNA splicing; neurological diseases; cancer; mRNA stability; NMDA RECEPTOR FUNCTION; 3'-UNTRANSLATED REGION; GLUCOSIDASE II; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; SYNAPTIC PLASTICITY; NERVOUS-SYSTEM; BETA-SUBUNIT; ETHANOL; EXPRESSION; ALCOHOL;

D O I：

10.3390/biom6010004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express a variety of RNA-binding proteins, which play important roles in the pathologies of a number of diseases. In this review we focus on the effect of alcohol on different RNA-binding proteins and their possible contribution to alcohol-related disorders, and discuss the role of these proteins in the development of neurological diseases and cancer. We further discuss the conventional methods and newer techniques that are employed to identify RNA-binding proteins.

引用

页码：2 / 18

页数：18

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