BARD1, a possible biomarker for breast and ovarian cancer

被引：18
|
作者：
Irminger-Finger, Irmgard [1 ,2 ]
机构：
[1] Univ Hosp Geneva, Mol Gynecol & Obstet Lab, Dept Gynecol & Obstet, CH-1211 Geneva, Switzerland
[2] Univ Hosp Geneva, Dept Med Genet & Lab, CH-1211 Geneva, Switzerland
来源：
GYNECOLOGIC ONCOLOGY | 2010年 / 117卷 / 02期
关键词：
BRCA1; BRCA2; Breast cancer; Ovarian cancer; Serum test; Isoforms; ESTROGEN-RECEPTOR-ALPHA; RNA-POLYMERASE-II; UBIQUITIN LIGASE; DNA-DAMAGE; BRCA1; IDENTIFICATION; ISOFORMS; PHOSPHORYLATION; SUSCEPTIBILITY; DEGRADATION;
D O I：
10.1016/j.ygyno.2009.10.079
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer is the leading cause of cancer death in women. Ovarian cancer, although less frequent, is detected very late, and survival is correlated to early detection. Therefore, better methods for early detection would help to increase the number of survivors. The incidence of young women diagnosed with breast cancer is increasing. These women and women who are at risk because of a family history of breast cancer would benefit from more accurate and less invasive screening methods than those in place today. A blood test based on BARD1, a protein that interacts with the breast cancer gene product BRCA1, is a promising candidate for fulfilling these conditions. The science behind BARD1 and its role in breast and ovarian cancer is explained in this article. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：211 / 215
页数：5
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