Metal-free cross-dehydrogenative coupling of benzimidazoles with aldehydes to N-acylbenzimidazoles

被引：18
|
作者：
Yu, Lin [1 ]
Wang, Min [1 ]
Wang, Lei [1 ,2 ]
机构：
[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON | 2014年 / 70卷 / 35期
基金：
美国国家科学基金会;
关键词：
Metal-free; Cross-dehydrogenative coupling; Benzimidazoles; Aldehydes; N-Acylbenzimidazoles; CATALYZED ONE-POT; MONOXIDE-FREE AMINOCARBONYLATION; AMIDE BOND FORMATION; SP(3) C-H; ARYL HALIDES; OXIDATIVE AMIDATION; CARBON-MONOXIDE; POLYSUBSTITUTED AMIDINES; EFFICIENT SYNTHESIS; PRIMARY ALCOHOLS;
D O I：
10.1016/j.tet.2014.07.009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and direct cross-dehydrogenative coupling (CDC) between benzimidazoles with aldehydes promoted by di-tert-butyl peroxide (DTBP) was developed. The reactions generated the corresponding N-acylbenzimidazoles in good yields under metal-free conditions. This method has broad substrate scope and high efficiency. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5391 / 5397
页数：7
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