Styrene maleic acid copolymer induces pores in biomembranes

被引：15

作者：

Rydmark, Marcella Orwick ^{[1
]}

Christensen, Mikkel Killingmoe ^{[2
]}

Koksal, Elif Senem ^{[2
]}

Kantarci, Ilayda ^{[2
]}

Kustanovich, Kiryl ^{[3
]}

Yantchev, Ventsislav ^{[3
]}

Jesorka, Aldo ^{[3
]}

Gozen, Irep ^{[2
,3
,4
]}

机构：

[1] Univ Oslo, Dept Biosci, N-0316 Oslo, Norway

[2] Univ Oslo, Fac Med, Ctr Mol Med Norway, N-0318 Oslo, Norway

[3] Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden

[4] Univ Oslo, Fac Math & Nat Sci, N-0315 Oslo, Norway

来源：

SOFT MATTER | 2019年 / 15卷 / 39期

基金：

欧盟地平线“2020”; 瑞典研究理事会;

关键词：

MEMBRANE-PROTEINS; PARTICLES; MIXTURES; VESICLES; INTACT; TOOL;

D O I：

10.1039/c9sm01407a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We investigated the interactions between styrene-maleic acid (SMA) copolymers and phospholipid bilayers, using confocal microscopy and surface acoustic wave resonance (SAR) sensing. For the first time we experimentally observed and followed pore formation by SMA copolymers in intact supported bilayers and unilamellar vesicles, showing that fluorescein, a water-soluble organic compound with a mean diameter of 6.9 angstrom, can traverse the membrane. Our findings are in agreement with recent theoretical predictions, which suggested that SMA copolymers may insert along the plane of the bilayer to form stable toroidal pores.

引用

页码：7934 / 7944

页数：11

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