Therapeutic potential of TGF-β inhibition in chronic renal failure

被引：35
|
作者：
Gagliardini, Elena [1 ]
Benigni, Ariela [1 ]
机构：
[1] Mario Negri Inst Pharmaceut Res, I-24125 Bergamo, Italy
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2007年 / 7卷 / 03期
关键词：
progressive nephropathies; proteinuria; renal fibrosis; transforming growth factor-beta;
D O I：
10.1517/14712598.7.3.293
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Chronic kidney diseases are emerging as a worldwide public health problem. The progression of kidney diseases closely correlates with the accumulation of extracellular matrix leading to glomerulosclerosis and tubulointerstitial injury. Transforming growth factor (TGF)-beta has been identified as a key mediator of kidney matrix accumulation. Overexpression of TGF-beta isoforms and their receptors was observed in a variety of renal diseases in both animals and humans. Given its crucial role in fibrotic kidney disease, TGF-beta has been recently considered as a possible target in the management of chronic renal diseases. This review discusses the role of TGF-beta in renal fibrosis and provides an overview of the strategies that, when interfering with TGF-beta expression and signalling, could be employed as new renoprotective treatments.
引用
收藏
页码：293 / 304
页数：12
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