Helicobacter pylori antibiotic resistance and [13C]urea breath test values

A correlation between 6 over baseline (DOB) values of the [C-13]urea breath test (UBT) and Helicobacter pylon clarithomycin resistance has been reported. suggesting a possible predictive role of UBT in therapeutic outcome. However, available data are limited and conflicting. This study aimed to clarify this issue, assessing the possible relationship between H pylon resistance towards different antibiotics (clarithromycin, metronidazole and levofloxacin) and UBT values The data showed similar DOB values between susceptible and resistant strains for clarithromycin (46 9 +/- 32.3 vs 45 7 +/- 30 6, P=0 8), metronidazole (46 4 +/- 29 6 vs 47 4 +/- 37 9, P=0 8), and levofloxacin (45 0 +/- 30.2 vs 54 2 +/- 38 4, P=0 08) Likewise, comparable DOB values were observed between susceptible and multidrug-resistant strains (45 4 +/- 29.6 vs 54 8 +/- 44.8, P=0.1). In conclusion, our data failed to find a significant correlation between UBT values and H pylon antibiotic resistance.