Emerging biomimetic nanotechnology in orthopedic diseases: progress, challenges, and opportunities

被引:44
|
作者
Zhang, Zhongyang [1 ,2 ]
Zhou, Jun [1 ,2 ]
Liu, Chuang [1 ,2 ]
Zhang, Jiaming [3 ]
Shibata, Yo [4 ]
Kong, Na [1 ,2 ]
Corbo, Claudia [5 ,6 ]
Harris, Mitchel B. [7 ]
Tao, Wei [1 ,2 ]
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
[3] Harvard Sch Dent Med, Dept Oral Med Infect & Immun, Div Bone & Mineral Res, Boston, MA 02115 USA
[4] Showa Univ, Dept Conservat Dent, Div Biomat & Engn, Sch Dent,Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan
[5] Univ Milano Bicocca, Nanomed Ctr Nanomib, Sch Med & Surg, I-20854 Vedano Al Lambro, Italy
[6] IRCCS Ist Ortoped Galeazzi, Milan, Italy
[7] Harvard Med Sch, Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02115 USA
来源
TRENDS IN CHEMISTRY | 2022年 / 4卷 / 05期
关键词
TARGETING DRUG-DELIVERY; BONE REGENERATION; NANOPARTICLES; OSTEOSARCOMA; CARTILAGE; COLLAGEN; SCAFFOLD; NANOCARRIERS; DOXORUBICIN; FABRICATION;
D O I
10.1016/j.trechm.2022.02.002
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Orthopedic diseases (e.g., fracture, bone tumor, osteoarthritis, osteoporosis, chronic inflammation, and infection) can result in locomotion disability, loss of protection for other soft tissues/organs, or dysfunction of hematopoiesis, mineral homeostasis, and other functions. The development of biomimetic nano-technology has advanced the innovation of orthopedic therapies for restoring the structure, composition, and biophysiological functions of the natural bone tissue. Identification of the pathogenesis and understanding the disease progression can greatly benefit the design and optimization of disease-specific therapy. Herein, we summarize guidelines on how biomimetic nanotechnology can be utilized in more efficiently treating various orthopedic diseases. We also discuss unmet needs and current challenges that might hinder the clinical implementation of biomimetic nanotechnology-based orthopedic therapies.
引用
收藏
页码:420 / 436
页数:17
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