Synthesis and biological evaluation of new benzo[f]furo[2,3-h]- and benzo[f]pyrano[2,3-h]coumarin derivatives.

被引：4
|
作者：
Tsoukka, Maria
Litinas, Konstantinos E. [1 ]
Nicolaides, Demetrios N.
Hadjipavlou-Litina, Dimitra J.
机构：
[1] Aristotle Univ Thessaloniki, Dept Chem, Organ Chem Lab, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 03期
关键词：
COUMARIN DERIVATIVES; MEDICINAL CHEMISTRY; ORTHO-QUINONES; ANALOGS; ANTIOXIDANTS; AGENTS;
D O I：
10.1002/jhet.5570440304
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Furocoumarins 3, 5 and pyranocoumarin 7 were synthesized from-the reaction of furonaphthalenediones 2, 4 and pyranonaphthalenedione 6 respectively with carbethoxymethylene(triphenyl)phosphorane in refluxing DCM for 3-6 hours or under microwave irradiation in toluene for a few minutes. Compounds 3, 5, 7 and their precursors were tested as anti-inflammatory/antioxidant agents. They were found to compete significantly high-DMSO for OH radicals, to scavenge O-2(-) and to inhibit lipoxygenase to a high extent.
引用
收藏
页码：529 / 534
页数：6
相关论文
共 50 条
  • [31] A SYNTHESIS OF NEW HETEROCYCLIC SYSTEM BENZOFURO[2,3-H]-1-OXAAZULENIUM
    BUTIN, AV
    ABAEV, VT
    KULNEVICH, VG
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1992, (08): : 1142 - 1143
  • [32] 2-Phenylpyrrolo[2,3-h]quinoline dihydrate
    Lynch, DE
    McClenaghan, I
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2002, 58 : O1150 - O1151
  • [33] Furo[2,3-h]Chromones and Pyrano[2,3:5,6]Chromeno [4,3-B]Pyridines Based on Natural Isoflavones
    Shokol, T. V.
    Gorbulenko, N. V.
    Frasinyuk, M. S.
    Khilya, V. P.
    CHEMISTRY OF NATURAL COMPOUNDS, 2018, 54 (06) : 1064 - 1067
  • [34] SYNTHESIS OF (4,9-DIMETHYL-2H-FURO-[2,3-H]-[1]-BENZOPYRAN--2-ON-6-OXY)ACETIC ACID AND ITS DERIVATIVES
    ZAWADOWSKI, T
    MAZUR, J
    POLISH JOURNAL OF CHEMISTRY, 1981, 55 (05) : 1151 - 1155
  • [35] A FACILE SYNTHESIS OF ANGULAR AND LINEAR 8/2-METHYL FURO[2,3-h]/[3,2-g] CHROMONES AND ANGULAR PYRANO[2,3-f] ISOFLAVONES FROM 7-PROPARGYLOXY CHROMONES AND ISOFLAVONES
    Daniel, V.
    Rao, Y. Jayaprakash
    Kumar, K. Santosh
    Krupadanam, G. L. David
    HETEROCYCLIC COMMUNICATIONS, 2008, 14 (05) : 337 - 344
  • [36] Facile Synthesis of 8-Hydroxymethyl-8,9-dihydro-2H-furo[2,3-h]chromene-3-carbaldehyde
    Kumar, V. V. A.
    Adiseshu, D.
    Mohanraju, K.
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (12) : 6738 - 6740
  • [37] POLYFURYL(ARYL)ALKANES AND THEIR DERIVATIVES .8. SYNTHESIS OF BENZOFURO[2,3-H]-1-OXAAZULENIUM SALTS - MOLECULAR AND CRYSTAL-STRUCTURE OF 2,4-DIMETHYLBENZO[B]FURO[2,3-H]-1-OXAAZULENIUM PERCHLORATE
    BUTIN, AV
    ABAEV, VT
    ZAVODNIK, VE
    KULNEVICH, VG
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1993, (05): : 627 - 632
  • [38] Tautomerism in the series of pyrrolo[2,3-h]-, -[3,2-f]-, -[2,3-f]-, -[3,2-g]-, AND -[3,2-h]quinolines
    S. A. Yamashkin
    E. A. Alyamkina
    Chemistry of Heterocyclic Compounds, 2009, 45 : 1121 - 1130
  • [39] SYNTHESIS OF SOME NEW S-SUBSTITUTED THIO[2,3-B]-BENZO[H]QUINOLINE AND THIENO[2,3-B]-BENZO[H]QUINOLINE DERIVATIVES
    BAKHITE, EA
    RADWAN, SM
    ELSAGHIER, AMM
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1995, 34 (02): : 97 - 101
  • [40] Azocoupling reactions of 4-methyldihydrofuro[2,3-h]coumarin-9-one
    Traven, VF
    Saharuk, II
    Kravtchenko, DV
    HETEROCYCLIC COMMUNICATIONS, 1998, 4 (05) : 429 - 436
12345